Search results for "computational analysis"
showing 10 items of 15 documents
The transcriptome of mouse central nervous system myelin
2016
AbstractRapid nerve conduction in the CNS is facilitated by insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics remains elusive. Here we performed a comprehensive transcriptome analysis (RNA-seq) of myelin biochemically purified from mouse brains at various ages and find a surprisingly large pool of transcripts enriched in myelin. Further computational analysis showed that the myelin transcriptome is closely related to the myelin proteome but clearly distinct from the transcriptomes of oligodendrocytes and brain tissues, suggesti…
Multivariate statistical analysis of a large odorants database aimed at revealing similarities and links between odorants and odors
2017
International audience; The perception of odor is an important component of smell; the first step of odor detection, and the discrimination of structurally diverse odorants depends on their interactions with olfactory receptors (ORs). Indeed, the perception of an odor's quality results from a combinatorial coding, in which the deciphering remains a major challenge. Several studies have successfully established links between odors and odorants by categorizing and classifying data. Hence, the categorization of odors appears to be a promising way to manage odors. In the proposed study, we performed a computational analysis using odor descriptions of the odorants present in Flavor-Base 9th Edit…
Numerical simulations on periprosthetic bone remodeling: a systematic review
2021
Abstract Background and objective The aim of the present study was to review the literature concerning the analysis of periprosthetic bone remodeling through finite element (FE) simulation. Methods A systematic review was conducted on 9 databases, taking into account a ten-year time period (from 2009 until 2020). The inclusion criteria were: articles published in English, publication date after 2009, full text articles, articles containing the keywords both in the abstract and in the title. The articles were classified through the following parameters: dimensionality of the simulation, modelling of the bone-prosthesis interface, output parameters, type of simulated prosthesis, bone remodeli…
'How Might Students engage with broader cultural questions relating to the circulation consumption, censorship, and reception of Decadent texts?'
2022
This paper explores the distribution of ‘Decadence’ ‘France’ ‘Decadent’ ‘French’ in British newspapers between 1890 and 1899 by relying on britishnewspaperarchive.co.ok It shows how the adjective was variously used in different contexts and how French Decadence was considered between 1880 and 1900.Not all 'decadence'/'decadent' was Decadent.Conversely exploring 'Décadence' in French periodicals yields different results but both digital repositories used in this research show that the noun was first used in a historical context.
Towards Big Data: Digitising Economic and Business History
2020
This chapter describes the experiences in computational and digital history of economic and business historians who for decades have been forerunners in digital history data gathering and computational analysis. It attempts to discuss the major developments within this area internationally and, in some specific cases, in Finland in the fields of digital economic and business history. It concentrates on a number of research projects that the authors have previously been involved in, as well as research outcomes by other economic and business historians within Finland and elsewhere. It is not claimed that the projects discussed are unique or ahead of their time in the field of economic and bu…
Development of a self-pumping extracorporeal blood oxygenation device characterized by a rotating shaft with embedded fiber packages.
2019
Introduction: To offer respiratory support for patients with lung disease, a novel technological solution for blood pumping and oxygenation is being developed. The pump–lung system was designed to integrate fiber membranes into six packages radially embedded in a rotating hollow shaft placed along the longitudinal axis of the device. Fiber packages are inclined with respect to the rotation axis so that the rotational motion of the rotating shaft allows a self-pumping system to be obtained. Method: Both hemodynamic and gas transfer performances were investigated using both in vitro experiments and in silico flow analyses. Results: The predicted flow velocity in the pump chamber was smooth an…
Computational Analysis Workshop: Comparing Four Approaches to Melodic Analysis
2009
We compare four computational approaches of melodic analysis according to diverse approach aspects: input type (monophonic or polyphonic), pattern identification type (strict or similar), analysis segmentation, aim of approach, motivic pattern representation, and type of result representations. The considered four computational approaches are the following: a similarity neighbourhood approach by Adiloglu (Adiloglu and Obermayer 2006a, b), a multiple viewpoint representation and discovery approach by Anagnostopoulou (Anagnostopoulou, Share and Conklin 2006), a topological approach by Buteau (2005), and an approach based on multidimensional closed pattern mining by Lartillot (Lartillot and To…
Computational analysis of lung deformation after murine pneumonectomy. [corrected].
2012
In many mammalian species, the removal of one lung (pneumonectomy) is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used microCT scanning to create 3-dimensional finite element geometric models of the murine lung pre- and post-pneumonectomy (24 hours). The structural correspondence between models was established using anatomic landmarks and an iterative computational algorithm. When compared with the pre-pneumonectomy lung, the post-pneumonectomy models demonstrated significant translation and rotation of the cardiac lobe into the post-pneumonectomy pleural space. 2-dimensional maps…
Computational analysis of positron experiments
1984
A number of applications of the calculational scheme developed by Puska and Nieminen (1982-3) are reported and the predictive power of the scheme is substantiated. Effects on positron parameters of relaxation and of N or H impurities in vacancies in Mo are calculated and employed to analyse recent experiments. Predictions pertaining to H decoration of vacancies in Al and Ni suggest the use of positron lifetime studies of these systems. Positron responses to submicroscopic vacancy clusters decorated with Kr and to large Kr bubbles in Cu are calculated and used to analyse recent experiments. To accomplish this the scheme is generalised to incorporate crystals of inert gas. In turn this makes …
Computational Analysis of Clinical and Molecular Markers and New Theranostic Possibilities in Primary Open-Angle Glaucoma
2020
Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results sho…